Search Results for: Nrf2

Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions: 1)Inflammation, 2)Genomic Instability (p53), and 3)Oxidative stress (Nrf2)

By James Watson, with contributions and editing by Vince Giuliano We promised a major series of blog entries related to inflammation back in May 2016.    We said we would do that through narrating a number of inter-related stories many of … Continue reading

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Prostate cancer – epigenetic factors, the role of Nrf2, cancer stem cells and actions of phytochemicals

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By Vince Giuliano There have been several important research findings in recent years relating to prostate cancer, ones that are transforming our views of the disease process and offering hopes for powerful new preventative and curative therapies.  This blog entry … Continue reading

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The pivotal role of Nrf2. Part 3 – Part 3 – Is promotion of Nrf2 expression a viable strategy for human human healthspan and lifespan extension?

By Vince Giuliano This is the third of three blog entries relating to the Nrf2 pathway.  The first blog entry The pivotal role of Nrf2. Part 1 – a new view on the control of oxidative damage and generation of … Continue reading

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The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2

By Vince Giuliano – updated Feb 8 and Feb 9, 2012 This is the second of three blog entries relating to the Nrf2 pathway.  The previous blog entry The pivotal role of Nrf2. Part 1 – a new view on … Continue reading

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The pivotal role of Nrf2. Part 1 – a new view on the control of oxidative damage and generation of hormetic effects

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The old free radical theory if aging is dead.  And, consuming excessive pure antioxidant supplements can be dangerous rather than health producing – see the blog entry End of the free radical theory of aging and negative consequences of indiscriminante … Continue reading

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Nrf2 and cancer chemoprevention by phytochemicals

A cluster of research reports has appeared during the last few years looking at  mechanisms through which substances rich in phytochemicals (e.g. coffee, chocolate, turmeric, olive oil, broccoli, red hot peppers, green tea, garlic, blueberries, rosemary, oregano, sage) are cancer-preventative. … Continue reading

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Unlocking Longevity

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By Vince Giuliano 9-27 -2023 Preface and a personal note In April of this year, I experienced a breakthrough in understanding human aging.  This was a key event for me, coming after 15 years of full-time study and writing 600 … Continue reading

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DEEPER INTO THE EPIGENETICS OF YOUNGING 1.1 — INTERACTIONS OF H3K9, H3K4, H3K27, H3K79 AND BIVALENT HISTONE POST-TRANSLATIONAL MODIFICATION (PMT) DOMAINS

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By Vince Giuliano.  With contributions, suggestions and editing by members of the YOUNGING team: Steve Buss, Walter Crompton, Chris Wikman and Debbie Coehlo 5-1-2022 GENERAL CONTEXT From the onset some 12 years ago, this anti-agingfirewalls blog has followed an implicit Mission … Continue reading

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ONLINE PRESENTATION – Extensions to Triggering Ancient Mechanisms For Rejuvenation — Online user comments, questions asked, and selected post-Meetup responses

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By Vince Giuliano and Steve Buss As announced previously, on November 20 2021 Steve Buss and I were featured in an online Meetup of the London Futurist group.  We focused on delivering a coherent presentation of our research reported in … Continue reading

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YGD YOUNGING1.0 PART 4: UNDERLYING MECHANISMS OF YOUNGING 1.0. HSC STEM CELL DIFFERENTIATION

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By Vince Giuliano Art KOUKOU by Vince Giuliano I.   INTRODUCTION AND BACKGROUND YOUNGING processes in the human body are like AGING processes in reverse. I have suggested that there are natural YOUNGING processes normally going on in mature humans, along … Continue reading

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