Comments on: Homicide by DNA methylation http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/ A weblog on the science and practices of living healthily very long - perhaps hundreds of years. Wed, 08 Sep 2010 20:36:03 +0000 http://wordpress.org/?v=2.2.1 By: admin http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4735 admin Fri, 30 Oct 2009 02:34:31 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4735 <p>Res CORRECTED REPLY</p> <p>Looking at the link you provided and the papers that cite that paper, it looks like indeed there is good work going on relating to demethylation as a cancer treatment. And it is much more advanced than I thought. I am reviewing a large number of studies and am preparing a new blog post on DNA demethylation.</p> Res CORRECTED REPLY

Looking at the link you provided and the papers that cite that paper, it looks like indeed there is good work going on relating to demethylation as a cancer treatment. And it is much more advanced than I thought. I am reviewing a large number of studies and am preparing a new blog post on DNA demethylation.

]]> By: admin http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4734 admin Fri, 30 Oct 2009 02:25:13 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4734 <p><p><p><p>Res: THIS IS A CORRECTED REPLY</p><br /><br /><br /> <p>29. October 2009 at 17:35 | edit<br /><br /><br /><br /> DNA methylation is rather gloomy indeed. There was a PBS program on the epigenomics. On how the grandchildren are more susceptible to Diabetes if the grandparents had faced famine. I thought about the implications of such discovery.</p><br /><br /><br /> <p>Yes indeed, being inheritable to some extent.</p><br /><br /><br /> <p>If it possible that the stemcells have the non DNA methylated pure code? If so, that template could be used for correcting or reversing such methylated DNA.</p><br /><br /><br /> <p>I am not completely clear about this. My impression is that a) some methylation markers are wiped out when cells are restored to iPSc status, and these are not inherited either, b) those methylation markers which are inherited, like the diabetes susceptibility you mentioned, definitely are in stem cells. They have to be if differentiated cells contain them.</p><br /><br /><br /> <p>Can selective demethyalation of specific places in the DNA possible? If so such reversals could lead to cure of the diseases.</p><br /><br /><br /> <p>My original impression was that demethylation is regularly done in-vitro but demethylation in-vivo is a reserch area that is really not up off the ground yet. I need to correct that as of 10/30 based on further looking at the literture. At least one cancer therapy using a demethylarion approach has gone through clinical trials and has resulted in a drug, and others are in the clinical trials pipeline. I am currently in the process of preparing a blog post on DNA DEmethylation.</p><br /><br /><br /> <p>Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells1<br /><br /><br /><br /> Ana Villar-Garea, Mario F. Fraga, Jesus Espada and Manel Esteller2<br /><br /><br /><br /> Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain </p><br /><br /><br /> <p>http://cancerres.aacrjournals.org/cgi/content/abstract/63/16/4984</p><br /><br /><br /> <p>Fascinating. Some of the Spanish research is really great. Looking at this lead led me off to discover a wealth of papers on DNA demethylation approaches to treating cancers.</p></p></p></p> <p><p><p>Res: THIS IS A CORRECTED REPLY</p><br /><br />
<p>29. October 2009 at 17:35 | edit<br /><br /><br />
DNA methylation is rather gloomy indeed. There was a PBS program on the epigenomics. On how the grandchildren are more susceptible to Diabetes if the grandparents had faced famine. I thought about the implications of such discovery.</p><br /><br />

<p>Yes indeed, being inheritable to some extent.</p><br /><br />
<p>If it possible that the stemcells have the non DNA methylated pure code? If so, that template could be used for correcting or reversing such methylated DNA.</p><br /><br />
<p>I am not completely clear about this. My impression is that a) some methylation markers are wiped out when cells are restored to iPSc status, and these are not inherited either, b) those methylation markers which are inherited, like the diabetes susceptibility you mentioned, definitely are in stem cells. They have to be if differentiated cells contain them.</p><br /><br />

<p>Can selective demethyalation of specific places in the DNA possible? If so such reversals could lead to cure of the diseases.</p><br /><br />
<p>My original impression was that demethylation is regularly done in-vitro but demethylation in-vivo is a reserch area that is really not up off the ground yet. I need to correct that as of 10/30 based on further looking at the literture. At least one cancer therapy using a demethylarion approach has gone through clinical trials and has resulted in a drug, and others are in the clinical trials pipeline. I am currently in the process of preparing a blog post on DNA DEmethylation.</p><br /><br />
<p>Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells1<br /><br /><br />
Ana Villar-Garea, Mario F. Fraga, Jesus Espada and Manel Esteller2<br /><br /><br />
Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain </p><br /><br />
<p>http://cancerres.aacrjournals.org/cgi/content/abstract/63/16/4984</p><br /><br />
<p>Fascinating. Some of the Spanish research is really great. Looking at this lead led me off to discover a wealth of papers on DNA demethylation approaches to treating cancers.</p></p></p>

]]> By: Res http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4730 Res Thu, 29 Oct 2009 18:42:34 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4730 Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells1 Ana Villar-Garea, Mario F. Fraga, Jesus Espada and Manel Esteller2 Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain http://cancerres.aacrjournals.org/cgi/content/abstract/63/16/4984 Procaine Is a DNA-demethylating Agent with Growth-inhibitory Effects in Human Cancer Cells1
Ana Villar-Garea, Mario F. Fraga, Jesus Espada and Manel Esteller2
Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain

http://cancerres.aacrjournals.org/cgi/content/abstract/63/16/4984

]]> By: Res http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4728 Res Thu, 29 Oct 2009 15:35:39 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4728 DNA methylation is rather gloomy indeed. There was a PBS program on the epigenomics. On how the grandchildren are more susceptible to Diabetes if the grandparents had faced famine. I thought about the implications of such discovery. If it possible that the stemcells have the non DNA methylated pure code? If so, that template could be used for correcting or reversing such methylated DNA. Can selective demethyalation of specific places in the DNA possible? If so such reversals could lead to cure of the diseases. DNA methylation is rather gloomy indeed. There was a PBS program on the epigenomics. On how the grandchildren are more susceptible to Diabetes if the grandparents had faced famine. I thought about the implications of such discovery.

If it possible that the stemcells have the non DNA methylated pure code? If so, that template could be used for correcting or reversing such methylated DNA.

Can selective demethyalation of specific places in the DNA possible? If so such reversals could lead to cure of the diseases.

]]> By: admin http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4725 admin Thu, 29 Oct 2009 00:36:42 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4725 <p><p>Hi bhartsh</p><br /> <p>I saw the link before but don't know how to interpret it without further context. Are these samples from different patients? If so, in what kinds of cells? After how long? It will be interesting to see how you respond to the cycloastragenol. I have been on it for about 10 days too and do not notice anything different from when I was on the astragaloside IV. I remain skeptical that telomere lengthening is a significant and strongly beneficial result of telomerase activation - although keeping them from getting too short could be. Check my recent post Pythons, cell senescence and telomere torments and my earler telomerase-related posts to get my views on why I have been taking a telomerase activator.</p></p> <p>Hi bhartsh</p>
<p>I saw the link before but don’t know how to interpret it without further context. Are these samples from different patients? If so, in what kinds of cells? After how long? It will be interesting to see how you respond to the cycloastragenol. I have been on it for about 10 days too and do not notice anything different from when I was on the astragaloside IV. I remain skeptical that telomere lengthening is a significant and strongly beneficial result of telomerase activation - although keeping them from getting too short could be. Check my recent post Pythons, cell senescence and telomere torments and my earler telomerase-related posts to get my views on why I have been taking a telomerase activator.</p>

]]> By: bhartsb http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4716 bhartsb Tue, 27 Oct 2009 22:11:28 +0000 http://anti-agingfirewalls.com/2009/10/26/homicide-by-dna-methylation/#comment-4716 Hi Vince, I posted this link earlier, but I don't think you saw it. Someone posted it to imminst. http://www.rechargebiomedical.com/blog/wp-content/misc_images/6mos_telomeres_v2.pdf I guess this comes from a doctor who is prescribing TA-65 to his patients. His own results didn't show much if any telomere lengthening, however these patients apparently had substantial lengthening. I've been trying Cycloastragenol myself for about 10 days and have not noticed any notable positive or negative effect from taking it. I did seem to have slightly flushed skin one evening about 12 hours after taking. Hi Vince,

I posted this link earlier, but I don’t think you saw it. Someone posted it to imminst.
http://www.rechargebiomedical.com/blog/wp-content/misc_images/6mos_telomeres_v2.pdf

I guess this comes from a doctor who is prescribing TA-65 to his patients. His own results didn’t show much if any telomere lengthening, however these patients apparently had substantial lengthening. I’ve been trying Cycloastragenol myself for about 10 days and have not noticed any notable positive or negative effect from taking it. I did seem to have slightly flushed skin one evening about 12 hours after taking.

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