Research evidence for the Decline In Adult Stem Cell Differentiation theory of aging.

26. July 2009 by admin.

A study published in the latest issue of the online journal Cell Stem Cell provides additional research evidence supporting the Decline in Adult Stem Cell Differentiation theory of aging, the 14^th theory treated in my treatise.  This theory holds that aging is due to a slowing rate of organ regeneration due to declining somatic cell differentiation activity.  This theory states that in addition to or perhaps instead of being concerned that aging is due to cells being damaged or reaching their reproductive  limit (such as according to the Oxidative Damage or the Telomere Shortening and Damage theories  of aging), we should be concerned that cells are not being replaced by freshly minted cells created by differentiating stem cells. 

The new study report TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance  indicates that “that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely.” “TAp63 / mice (mice with TAp63 knocked out) age prematurely and develop blisters, skin ulcerations, senescence of hair follicle-associated dermal and epidermal cells, and decreased hair morphogenesis.” – “These data indicate that TAp63 serves to maintain adult skin stem cells by regulating cellular senescence and genomic stability, thereby preventing premature tissue aging(ref).” 

Again the message is that if you are worried about aging, be concerned with the supply chain for new somatic cells.  Start focusing on what is happening to adult stem cells. 

Posted in Uncategorized | 1 Comment »