Comments on: Progerin, HGPS and a possible new theory of aging http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/ A weblog on the science and practices of living healthily very long - perhaps hundreds of years. Thu, 09 Sep 2010 10:12:12 +0000 http://wordpress.org/?v=2.2.1 By: admin http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1093 admin Tue, 12 May 2009 18:19:11 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1093 Res Regarding the article you suggested I look at, it is one of several that deal with the issue of telomerase geometric structure and helicases - an arcane and complex area of research related to telomere shortning I need to look further into. My impression at this point is that the researchers working in that area and the researchers concerned with FTIs and snd progerin are different bunches who probably don't read each other's stuff or talk to each other. It may or may not be possible at this point to develop conjectures that relate the two areas but I am far from being there. As you probably know Werner's Syndrome is yet another genetic disease of premature aging different from HGPS, involving yet another set of genes. There do appear to be research linkages relating Werner's Syndrom to telomere architecture and shortning, and I am going to have a look at those later today. Vince Res
Regarding the article you suggested I look at, it is one of several that deal with the issue of telomerase geometric structure and helicases - an arcane and complex area of research related to telomere shortning I need to look further into. My impression at this point is that the researchers working in that area and the researchers concerned with FTIs and snd progerin are different bunches who probably don’t read each other’s stuff or talk to each other. It may or may not be possible at this point to develop conjectures that relate the two areas but I am far from being there.
As you probably know Werner’s Syndrome is yet another genetic disease of premature aging different from HGPS, involving yet another set of genes. There do appear to be research linkages relating Werner’s Syndrom to telomere architecture and shortning, and I am going to have a look at those later today. Vince

]]> By: Res http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1088 Res Tue, 12 May 2009 14:50:09 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1088 Hi Vince http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1Y-4VP4WC0-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f1e427f1d0bb55497b65477548997fe9 The above article in full if available could shed some information on telomeres statins and progerin. Hi Vince

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1Y-4VP4WC0-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=f1e427f1d0bb55497b65477548997fe9

The above article in full if available could shed some information on telomeres statins and progerin.

]]> By: admin http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1064 admin Mon, 11 May 2009 22:09:33 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1064 Prophets Good questi:on about FTIs being potentially useful to treat cardiovascular disease. As of now, I don't know. I plan to look more into FTIs and plan to write more up on the whole subject. Vince Prophets
Good questi:on about FTIs being potentially useful to treat cardiovascular disease. As of now, I don’t know. I plan to look more into FTIs and plan to write more up on the whole subject.
Vince

]]> By: admin http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1063 admin Mon, 11 May 2009 22:06:07 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1063 <p>Res<br /> As to progerin inducing disease phenotypes of progeria even when it is not farmesylated, I am not surprised because progerin lacks a chain of 50 amino acids that is spliced out of normal LMNA. Apparently farnesylation and gene deletion are separate issues with progerin.</p> <p>As to imatrib bringing back black hair, most interesting! Some of the white hair on my previously-bald scalp has been slowly coming back since I started taking astragaloside IV. I have been wondering about what it would take to turn it black as a next step. I am not going to take imatrib but will see if I can find out how it works to turn hair black.</p> <p>As to statins being FTIs, also interesting. As you may know I have mixed feelings about them.. I will check the Google ref you sent.<br /> Vince</p> Res
As to progerin inducing disease phenotypes of progeria even when it is not farmesylated, I am not surprised because progerin lacks a chain of 50 amino acids that is spliced out of normal LMNA. Apparently farnesylation and gene deletion are separate issues with progerin.

As to imatrib bringing back black hair, most interesting! Some of the white hair on my previously-bald scalp has been slowly coming back since I started taking astragaloside IV. I have been wondering about what it would take to turn it black as a next step. I am not going to take imatrib but will see if I can find out how it works to turn hair black.

As to statins being FTIs, also interesting. As you may know I have mixed feelings about them.. I will check the Google ref you sent.
Vince

]]> By: Res http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1057 Res Mon, 11 May 2009 17:37:09 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1057 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2525700 Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated These data support the concept that inhibition of protein farnesylation in progeria could be therapeutically useful but also suggest that this approach may be limited, as progerin elicits disease phenotypes whether or not it is farnesylated http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2525700

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

These data support the concept that inhibition of protein farnesylation in progeria could be therapeutically useful but also suggest that this approach may be limited, as progerin elicits disease phenotypes whether or not it is farnesylated

]]> By: Res http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1051 Res Mon, 11 May 2009 13:39:50 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1051 FTIs are not exotic medications. Statins are also FTIs. Check google http://www.google.com/search?hl=en&q=farnesylation+statin FTIs are not exotic medications.
Statins are also FTIs.

Check google
http://www.google.com/search?hl=en&q=farnesylation+statin

]]> By: Res http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1050 Res Mon, 11 May 2009 13:30:33 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1050 on a side note, Imatinib (Gleevec) restores the blackness to gray hair http://news.bbc.co.uk/2/hi/health/2180244.stm This is also a cancer medication. More research is needed. on a side note, Imatinib (Gleevec) restores the blackness to gray hair

http://news.bbc.co.uk/2/hi/health/2180244.stm

This is also a cancer medication.

More research is needed.

]]> By: Res http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1049 Res Mon, 11 May 2009 13:19:42 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1049 Thanks Vince Nice summarization. Thanks Vince
Nice summarization.

]]> By: prophets http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1031 prophets Mon, 11 May 2009 02:14:12 +0000 http://anti-agingfirewalls.com/2009/05/10/progerin-hgps-and-a-possible-new-theory-of-aging/#comment-1031 interesting, what are your thoughts about it being used as a treatment for cardiovascular disease in general? interesting, what are your thoughts about it being used as a treatment for cardiovascular disease in general?

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